Oxcarbazepine (OX) and quetiapine fumarate (QF) are poorly water-soluble drugs and bioavailability is very low. The objective of the research was to increase the solubility and dissolution rate of drugs by formulating a solid dispersion with pluronic polymers F127, F87 and F108 using hot melt method. The dissolution profiles of developed formulations were studied. Drug–polymer interactions also were investigated using differential scanning calorimetry (DSC) and Fourier transform infrared spectroscopy (FTIR). For the preparation of oxcarbazepine and quetiapine fumarate fast-dissolve tablets, a 1:2 solid dispersion with pluronic polymers F127, F87 and F108 was used with croscarmellose sodium as a superdisintegrant and pearlitol 200SD (pearlitol) as a pore-forming agent. Also studied was disintegration time, percentage friability, wettability and percentage of drug released etc. The results showed that a dispersion of the drug in polymer considerably enhanced the dissolution rate. The drug-to-carrier ratio is the controlling factor for dissolution improvement. FTIR spectra show no chemical incompatibility between the drug and pluronic polymers F127, F87 and F108. FTIR and DSC data indicate that oxcarbazepine and quetiapine fumarate was in the amorphous form, which explains the faster dissolution rate of the drug from its solid dispersions. Concerning the optimization study, different analysis revealed that an optimum concentration of croscarmellose sodium and a higher percentage of pearlitol are required for obtaining rapidly disintegrating tablets.
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